The Museum features artifacts and replicas of items related to the Karankawa Indians who were the native inhabitants of this area. It also features 3 murals depicting the Karankawas way of life.
The museum features an exhibit about Palacios' role along with items found in the excavation and includes a feature length film about the Excavation of La Belle.
La Petite Belle is a half scale seaworthy reproduction of Rene-Robert Cavelier’s ship LaBelle. It is currently located within walking distance from the museum at the South Bay Marina.
Camp Hulen began as a Texas National Guard Camp in the mid-1920s and became an Army base during WWII in the 1940s. Rita Hayworth, Artie Shaw, and other entertainers came to entertain the troops.
Palacios is known as the Shrimp Capital of Texas. The shrimping industry began in the 1920s with the Bates being the first shrimping family to settle in Palacios. This exhibit features tools from the beginnings of the shrimping industry to the present.
Agriculture was and still is a big part of Palacios' way of life. The museum features a collection of farm implements and ranch tools from the 19th and 20th Centuries.
The first school opened in Palacios in 1905. This exhibit tells about the early beginnings of Palacios ISD to the present day.
The museum exhibits the history about 2 doctors who practiced medicine in Palacios in the early 1900s to 1980s. The exhibits features medical tools donated by Dr. Sanford's family.